Compile Data Set for Download or QSAR
Found 130 of ic50 for UniProtKB: P22102
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016658(2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteri...)copy SMILEScopy InChI
Affinity DataIC50: 0nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K27J9PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016662(2-{4-[3-(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin...)copy SMILEScopy InChI
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K27J9PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016659(2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteri...)copy SMILEScopy InChI
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K27J9PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016660(2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteri...)copy SMILEScopy InChI
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K27J9PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016658(2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteri...)copy SMILEScopy InChI
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of the GAR transformylase in MOLT-4 human leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K27J9PubMed
LigandPNGBDBM50277355(CHEMBL4177183)copy SMILEScopy InChI
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7M6FPubMed
LigandPNGBDBM50277352(CHEMBL4162649)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7M6FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50543845(CHEMBL4643623)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z98G2PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534427(CHEMBL4437824)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50393640(CHEMBL2158681)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50503238(CHEMBL4465095)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50543843(CHEMBL4636872)copy SMILEScopy InChI
Affinity DataIC50: 0.950nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z98G2PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50126172(CHEMBL3628344)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50503236(CHEMBL4538151)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50503240(CHEMBL4445651)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50457435(CHEMBL4214638)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z98G2PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50393640(CHEMBL2158681)copy SMILEScopy InChI
Affinity DataIC50: 1.79nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50354833(AGF94 | CHEMBL1834488)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50457435(CHEMBL4214638)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SF1PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171511((S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50354833(AGF94 | CHEMBL1834488)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human KB cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs by ion-exchang...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F47QQSPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50503239(CHEMBL4557278)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048QFPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50393639(CHEMBL2158682)copy SMILEScopy InChI
Affinity DataIC50: 2.03nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534430(CHEMBL4471269)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50126172(CHEMBL3628344)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50543844(CHEMBL4645676)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z98G2PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50126174(CHEMBL3628346)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534427(CHEMBL4437824)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50442985(CHEMBL3086865)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as incorporation of [U-14C]-glycine into [14C]-formyl glycinamide ribon...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9CSQPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 3.46nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1ZB5PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50354833(AGF94 | CHEMBL1834488)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7K3PPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50457432(CHEMBL4205344)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ST7SF1PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534426(CHEMBL4553188)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534428(CHEMBL4467936)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50543847(CHEMBL4638232)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z98G2PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50442984(AGF147 | CHEMBL3086866)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534429(CHEMBL4444011)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171511((S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50005518((S)-2-(4-(2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahyd...)copy SMILEScopy InChI
Affinity DataIC50: 5.77nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1ZB5PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50534431(CHEMBL4447805)copy SMILEScopy InChI
Affinity DataIC50: 6.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4V5FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50171511((S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM192709(AGF117)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.5Assay Description:GARFTase activity was determined by measuring the rate of 5,8-dideazatetrahydrofolate production in the presence of varying concentrations of antifol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q270806HPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50272272(CHEMBL502528 | N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24F1RNBPubMed
LigandPNGBDBM50277353(CHEMBL4170578)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7M6FPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50272273(CHEMBL526928 | N-{4-[6-(2-Amino-4-oxo-4,7-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24F1RNBPubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM192710(AGF118)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.5Assay Description:GARFTase activity was determined by measuring the rate of 5,8-dideazatetrahydrofolate production in the presence of varying concentrations of antifol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q270806HPubMed
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