Compile Data Set for Download or QSAR
Found 221 of ic50 for UniProtKB: P25786
LigandPNGBDBM50531806(CHEMBL4460323)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V127JJPubMed
LigandPNGBDBM50531814(CHEMBL4517600)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50514365(CHEMBL4587036)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9VGVPubMed
LigandPNGBDBM50531815(CHEMBL4444107)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50531807(CHEMBL4541038)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
TargetProteasome subunit alpha type-1(Homo sapiens (Human))TBA
LigandPNGBDBM50577134(CHEMBL4877708)copy SMILES
Affinity DataIC50: 3.80nMAssay Description:Inhibition of caspase-like activity of human proteasome beta-1c subunit using SUC-LLE-AMC as flurogenic substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WZNPubMed
LigandPNGBDBM50531812(CHEMBL4547405)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50514367(CHEMBL4581126)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9VGVPubMed
LigandPNGBDBM50531826(CHEMBL4558648)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50531813(CHEMBL4542373)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50531808(CHEMBL4467618)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V127JJPubMed
LigandPNGBDBM50531825(CHEMBL4435814)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50514366(CHEMBL4447701)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9VGVPubMed
LigandPNGBDBM50531816(CHEMBL4436430)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human 20S proteasome chymotrypsin-like activity in human RPMI-8226 cells using Suc-LLVY-AMC as fluorogenic substrate incubated for 3 hr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9GWMPubMed
LigandPNGBDBM50475041(CHEMBL181131 | TP-104)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determinedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9SVNPubMed
LigandPNGBDBM50469762(CHEMBL432281)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2XV2PubMed
LigandPNGBDBM50531811(CHEMBL4559271)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50531833(CHEMBL4572638)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50531832(CHEMBL4441018)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
LigandPNGBDBM50531809(CHEMBL4578081)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50475039(CHEMBL181025 | TP-103)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determinedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9SVNPubMed
LigandPNGBDBM50531822(CHEMBL4443333)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2F38PubMed
LigandPNGBDBM50398609(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
LigandPNGBDBM50571145(CHEMBL4875208)copy SMILES
Affinity DataIC50: 16nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67MQ5PubMed
LigandPNGBDBM50571135(CHEMBL4864661)copy SMILES
Affinity DataIC50: 16nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67MQ5PubMed
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