TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 29nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 76nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 77nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 131nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 146nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 174nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 192nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 205nMAssay Description:Modulation of recombinant human GABA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as change in GABA-induced current at -80 mV holdin...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 299nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 321nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 379nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 470nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 577nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 744nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 844nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 937nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >1.00E+3nMAssay Description:Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currentsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 1.17E+3nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 1.24E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 1.36E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.50E+3nMAssay Description:Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytes at 1 mMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 1.60E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 2.01E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States.
Curated by ChEMBL
Affinity DataEC50: 2.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+3nMAssay Description:Positive allosteric modulation of GABAA alpha1beta3 in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins b...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3.02E+3nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 5.15E+3nMAssay Description:Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha4-beta3-gamma2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha4-beta3-gamma2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 2.80E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 5.50E+4nMAssay Description:Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytes at 1 mMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 6.50E+4nMAssay Description:Agonist activity on human Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.40E+5nMAssay Description:Agonist activity on human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Agonist activity on human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 1.80E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.40E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3.00E+5nMAssay Description:Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytes at 1 mMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3.70E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.60E+5nMAssay Description:Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytes at 1 mMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 3.00E+6nMAssay Description:Agonist activity on human Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals
Curated by ChEMBL
AstraZeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 4.90E+6nMAssay Description:Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair