Compile Data Set for Download or QSAR
Found 167 of ec50 for UniProtKB: P42336
LigandPNGBDBM50336882(CHEMBL1672327 | N6-(6-(1-methylpiperidin-4-yloxy)p...)copy SMILEScopy InChI
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
LigandPNGBDBM50426176(CHEMBL2316958)copy SMILEScopy InChI
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3Kalpha in human SKOV3 cells assessed as inhibition of Akt Ser473 phosphorylation at 1 to 1000 nM after 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
LigandPNGBDBM295669((S)-2-cyclopropyl-2-((2-((S)-4- (fluoromethyl)-2-o...)copy SMILEScopy InChI
Affinity DataEC50:  27nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46X11PubMed
LigandPNGBDBM50439721(CHEMBL2418953)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140272(CHEMBL3754572)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140269(CHEMBL3752653)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140267(CHEMBL3752019)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140266(CHEMBL3753366)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140265(CHEMBL3753450)copy SMILEScopy InChI
Affinity DataEC50: <40nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)copy SMILEScopy InChI
Affinity DataEC50:  40nMAssay Description:Inhibition of wild type PI3Kalpha (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0JVHPubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)copy SMILEScopy InChI
Affinity DataEC50:  40nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50336880(2-morpholino-N6-(quinolin-3-yl)-4,5'-bipyrimidine-...)copy SMILEScopy InChI
Affinity DataEC50:  40nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
LigandPNGBDBM50315213(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Inhibition of wild type PI3Kalpha (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0JVHPubMed
LigandPNGBDBM50315213(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0JVHPubMed
LigandPNGBDBM50315213(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50315213(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50140270(CHEMBL3752503)copy SMILEScopy InChI
Affinity DataEC50:  60nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50439711(CHEMBL2418954)copy SMILEScopy InChI
Affinity DataEC50:  80nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50140275(CHEMBL3752775)copy SMILEScopy InChI
Affinity DataEC50:  90nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50336865(CHEMBL1672328 | N6-(6-methoxypyridin-3-yl)-2-morph...)copy SMILEScopy InChI
Affinity DataEC50:  90nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
LigandPNGBDBM50468940(CHEMBL4291904)copy SMILEScopy InChI
Affinity DataEC50:  93nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50365506(CHEMBL1957497)copy SMILEScopy InChI
Affinity DataEC50:  93nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50468968(CHEMBL4294052)copy SMILEScopy InChI
Affinity DataEC50:  97nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50140273(CHEMBL3752760)copy SMILEScopy InChI
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50336881(2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyr...)copy SMILEScopy InChI
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
LigandPNGBDBM50336875(CHEMBL1672324 | N2'-methyl-2-morpholino-N6-(quinol...)copy SMILEScopy InChI
Affinity DataEC50:  110nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
LigandPNGBDBM50365517(CHEMBL1957508)copy SMILEScopy InChI
Affinity DataEC50:  114nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)copy SMILEScopy InChI
Affinity DataEC50:  130nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
LigandPNGBDBM50468940(CHEMBL4291904)copy SMILEScopy InChI
Affinity DataEC50:  137nMAssay Description:Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50365510(CHEMBL1957501)copy SMILEScopy InChI
Affinity DataEC50:  138nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50140271(CHEMBL3751961)copy SMILEScopy InChI
Affinity DataEC50:  150nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50468968(CHEMBL4294052)copy SMILEScopy InChI
Affinity DataEC50:  169nMAssay Description:Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85KTPubMed
LigandPNGBDBM50140268(CHEMBL3753085)copy SMILEScopy InChI
Affinity DataEC50:  170nMAssay Description:Inhibition of PI3Kalpha in human A2780 cells assessed as reduction of AKT phosphorylation at Ser473 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP76SBPubMed
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataEC50:  200nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S8HPubMed
LigandPNGBDBM50365516(CHEMBL1957507)copy SMILEScopy InChI
Affinity DataEC50:  200nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50365508(CHEMBL1957499)copy SMILEScopy InChI
Affinity DataEC50:  203nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50365507(CHEMBL1957498)copy SMILEScopy InChI
Affinity DataEC50:  208nMAssay Description:Inhibition of PI3K p110alpha/p85alpha-mediated AKT1 phosphorylation at Ser473 in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95DXPubMed
LigandPNGBDBM50336878(2-morpholino-N6-(tetrahydro-2H-pyran-4-yl)-4,5'-bi...)copy SMILEScopy InChI
Affinity DataEC50:  220nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56K0RPubMed
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