Compile Data Set for Download or QSAR
Found 566 of ic50 for UniProtKB: P49810
LigandPNGBDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50410179(CHEMBL2096800)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z94C2PubMed
LigandPNGBDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50185414((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50185405((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50185413((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50185408((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50171224(CHEMBL196215 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237788HPubMed
LigandPNGBDBM50185406((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50185412((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445KZQPubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393452(CHEMBL2159511)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41PQPubMed
LigandPNGBDBM50171213(CHEMBL194788 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237788HPubMed
LigandPNGBDBM50223758(CHEMBL58925)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50185409((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50185403((+/-)-(4aS,6R,8aS)-3-tert-butyl-6-(4-chloro-benzen...)copy SMILEScopy InChI
Affinity DataIC50: 1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V3CPubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50129274(CHEMBL3629745)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50129274(CHEMBL3629745)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50171219(CHEMBL198301 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237788HPubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393453(CHEMBL2159510)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41PQPubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50189039(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TN8PubMed
LigandPNGBDBM50129273(CHEMBL3629744)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of gamma-secretase as amyloid peptide production in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5M9MPubMed
LigandPNGBDBM50186575(CHEMBL377206 | cis-methyl 4-(3-(4-chlorophenylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02DTPubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41PQPubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41PQPubMed
LigandPNGBDBM50171215(CHEMBL198302 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237788HPubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50171223(CHEMBL195551 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237788HPubMed
LigandPNGBDBM50223748(CHEMBL406322)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
LigandPNGBDBM50129278(CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50129273(CHEMBL3629744)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ41R9PubMed
LigandPNGBDBM50151297(CHEMBL3771056)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Modulation of gamma-secretase activity (unknown origin) assessed as amyloid-beta(1-42) production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81FXRPubMed
LigandPNGBDBM50223752(CHEMBL117978)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
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