Compile Data Set for Download or QSAR
Found 229 of ec50 for UniProtKB: P47870
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50055963(1-[(3R,5R,10S,13S,17S)-3-(4-Acetyl-phenylethynyl)-...)copy SMILEScopy InChI
Affinity DataEC50:  6.60nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454531(CHEMBL3138433)copy SMILEScopy InChI
Affinity DataEC50:  8.20nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)copy SMILEScopy InChI
Affinity DataEC50:  9nMAssay Description:Binding affinity to human alpha1beta2gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB536XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454527(CHEMBL3138291)copy SMILEScopy InChI
Affinity DataEC50:  18nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454526(CHEMBL3138293)copy SMILEScopy InChI
Affinity DataEC50:  31nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50215531(2-chloro-alpha-[[(4-chlorophenyl)amino]methylene]-...)copy SMILEScopy InChI
Affinity DataEC50:  34nMAssay Description:Activity at human GABAA alpha-1-beta-2-gamma-2L expressed in Xenopus oocytes assessed as potentiation of GABA currentsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TB7PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50282235(CHEMBL4174166)copy SMILEScopy InChI
Affinity DataEC50:  70nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076TSPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataEC50:  85nMAssay Description:Binding affinity to human alpha1beta2gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataEC50:  100nMAssay Description:Allosteric modulation of GABAA alpha1beta2gamma2 (unknown origin) expressed in Xenopus oocytes assessed as potentiation of GABA-induced current respo...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258256(CHEMBL3427532)copy SMILEScopy InChI
Affinity DataEC50:  125nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50055919(1-((3R,5S,10S,13S,17S)-3-Azidomethyl-3-hydroxy-10,...)copy SMILEScopy InChI
Affinity DataEC50:  150nMAssay Description:Potentiation of GABA-activated currents in Xenopus oocytes expressing cloned human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0463JPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)copy SMILEScopy InChI
Affinity DataEC50:  160nMAssay Description:Potentiation of GABA-activated currents in Xenopus oocytes expressing cloned human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50282234(CHEMBL4163464)copy SMILEScopy InChI
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076TSPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50504738(CHEMBL4463715)copy SMILEScopy InChI
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of recombinant human GABA receptor alpha1beta2gamma2 expressed in CHO cells at 30 uM in presence of GABA and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B05RJPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258254(CHEMBL4073780)copy SMILEScopy InChI
Affinity DataEC50:  225nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)copy SMILEScopy InChI
Affinity DataEC50:  237nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50207314(CHEMBL3971200)copy SMILEScopy InChI
Affinity DataEC50:  238nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B911ZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)copy SMILEScopy InChI
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50504737(CHEMBL4539102)copy SMILEScopy InChI
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of recombinant human GABA receptor alpha1beta2gamma2 expressed in CHO cells at 30 uM in presence of GABA and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B05RJPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50369240(GANAXOLONE)copy SMILEScopy InChI
Affinity DataEC50:  260nMAssay Description:Potentiation of GABA-activated currents in Xenopus oocytes expressing cloned human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0463JPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)copy SMILEScopy InChI
Affinity DataEC50:  290nMAssay Description:Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currentsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258252(CHEMBL4073679)copy SMILEScopy InChI
Affinity DataEC50:  291nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50055953(1-[(3R,5R,10S,13S,17S)-3-Hydroxy-3-(2-hydroxy-phen...)copy SMILEScopy InChI
Affinity DataEC50:  340nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)copy SMILEScopy InChI
Affinity DataEC50:  374nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC92NRPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)copy SMILEScopy InChI
Affinity DataEC50:  375nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50332375(4-Amino-8-(5-(azetidine-1-carbonyl)pyridin-3-yl)-N...)copy SMILEScopy InChI
Affinity DataEC50:  389nMAssay Description:Binding affinity to human alpha1beta2gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB536XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454499(CHEMBL3137990)copy SMILEScopy InChI
Affinity DataEC50:  390nMAssay Description:Potentiation of GABA-activated currents in Xenopus oocytes expressing cloned human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0463JPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50207312(CHEMBL3954951)copy SMILEScopy InChI
Affinity DataEC50:  408nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B911ZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50600438(CHEMBL5177165)copy SMILES
Affinity DataEC50:  500nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64P33PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50282235(CHEMBL4174166)copy SMILEScopy InChI
Affinity DataEC50:  500nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076TSPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50164570((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...)copy SMILEScopy InChI
Affinity DataEC50:  500nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076TSPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50409548(CHEMBL29790)copy SMILEScopy InChI
Affinity DataEC50:  501nMAssay Description:Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN17DVPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50052792(CHEBI:7035 | Muscimol)copy SMILEScopy InChI
Affinity DataEC50:  537nMAssay Description:Agonist activity at human GABAAalpha1beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3P4ZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50052792(CHEBI:7035 | Muscimol)copy SMILEScopy InChI
Affinity DataEC50:  540nMAssay Description:Agonist activity at human GABAAalpha1beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3P4ZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50459890(Bromophene | CHEBI:70620)copy SMILEScopy InChI
Affinity DataEC50:  720nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC92NRPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM540734(US11261211, Compound SA-1)copy SMILES
Affinity DataEC50:  750nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2988B61US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM540735(US11261211, Compound SA-2)copy SMILES
Affinity DataEC50:  750nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2988B61US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258217(CHEMBL3427530)copy SMILEScopy InChI
Affinity DataEC50:  979nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454529(CHEMBL3138315)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+3nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50454528(CHEMBL3138292)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+3nMAssay Description:Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN731XPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258229(CHEMBL4103751)copy SMILEScopy InChI
Affinity DataEC50:  1.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258239(CHEMBL4091891)copy SMILEScopy InChI
Affinity DataEC50:  1.16E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  1.20E+3nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50282234(CHEMBL4163464)copy SMILEScopy InChI
Affinity DataEC50:  1.23E+3nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076TSPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50207313(CHEMBL3962969)copy SMILEScopy InChI
Affinity DataEC50:  1.27E+3nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B911ZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50600440(CHEMBL5173230)copy SMILES
Affinity DataEC50:  1.40E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64P33PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM50258253(CHEMBL4085062)copy SMILEScopy InChI
Affinity DataEC50:  1.50E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5K4WPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM540739(US11261211, Compound SA-8)copy SMILES
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2988B61US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
CoCensys, Inc.

Curated by ChEMBL
LigandPNGBDBM540736(US11261211, Compound SA-4)copy SMILES
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2988B61US Patent
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