TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 0.600nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 1.40nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 4.70nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 5.20nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 5.70nMAssay Description:Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 6nMAssay Description:Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 6.20nMAssay Description:Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 7nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 8.10nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 9nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 9nMAssay Description:Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 9.10nMAssay Description:Agonist activity at muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 9.10nMAssay Description:Agonist activity at muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Positive allosteric modulation of human M4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Positive allosteric modulation of human M4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at muscarinic human M4 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
In DepthDetails
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 12.6nMAssay Description:Agonist activity at human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 chimaeric G-protein assessed as effect on calcium mobiliza...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Agonist activity at human muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
The University of Toledo
Curated by ChEMBL
The University of Toledo
Curated by ChEMBL
Affinity DataEC50: 19nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair