Compile Data Set for Download or QSAR
Found 23 of ec50 for UniProtKB: P36897
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21513(7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 72nM EC50:  17nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21510(Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21506(Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21508(7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-[2-(pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 100nM EC50:  38nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 59nM EC50:  40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21504(7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 74nM EC50:  44nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21496(6-bromo-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 89nM EC50:  55nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21507(Dihydropyrrolopyrazole, 15b | ethyl(methyl)[2-({4-...)copy SMILEScopy InChI
Affinity DataIC50: 85nM EC50:  61nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)copy SMILEScopy InChI
Affinity DataIC50: 33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21512(7-(oxolan-2-ylmethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6...)copy SMILEScopy InChI
Affinity DataIC50: 130nM EC50:  80nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)copy SMILEScopy InChI
Affinity DataIC50: 69nM EC50:  180nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21503(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)copy SMILEScopy InChI
Affinity DataIC50: 160nM EC50:  200nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21497(4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 141nM EC50:  201nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21511(1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 49nM EC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21498(Dihydropyrrolopyrazole, 8 | methyl 4-[2-(6-methylp...)copy SMILEScopy InChI
Affinity DataIC50: 526nM EC50:  403nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21499(Dihydropyrrolopyrazole, 9 | N-[2-(dimethylamino)et...)copy SMILEScopy InChI
Affinity DataIC50: 193nM EC50:  468nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21495(8-fluoro-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 928nM EC50:  951nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21494(6,8-dimethoxy-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H...)copy SMILEScopy InChI
Affinity DataIC50: 3.81E+3nM EC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21517(Dihydropyrrolopyrazole, 22 | N,N-dimethyl-4-({4-[2...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nM EC50:  1.50E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21516(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21502(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21501(2-(ethylsulfanyl)-4-[2-(pyridin-2-yl)-4H,5H,6H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21493(2-chloro-4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.98E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed