Compile Data Set for Download or QSAR
Found 27 of ec50 for UniProtKB: P0C6X6
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM50281169(CHEMBL4173846 | US20240034730, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  12nMMore data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648427(US20240033256, Compound 2)copy SMILES
Affinity DataEC50:  16.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521551(2-Ethylbutyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,...)copy SMILES
Affinity DataEC50:  25nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)copy SMILEScopy InChI
Affinity DataEC50:  43nMMore data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM484194(UAWJ9-36-1)copy SMILEScopy InChI
Affinity DataEC50:  46nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8GWQPubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648429(US20240033256, Compound 4)copy SMILES
Affinity DataEC50:  51.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648428(US20240033256, Compound 3)copy SMILES
Affinity DataEC50:  55.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521549(Diisopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1...)copy SMILES
Affinity DataEC50:  56nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM484195(UAWJ9-36-3)copy SMILEScopy InChI
Affinity DataEC50:  59nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8GWQPubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM448319(GC-376 | GC376)copy SMILEScopy InChI
Affinity DataEC50:  60nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8GWQPubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521546(US11149049, No. C1)copy SMILES
Affinity DataEC50:  65nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648426(US20240033256, Compound 1)copy SMILES
Affinity DataEC50:  68nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)copy SMILES
Affinity DataEC50:  74nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MFK
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521550(Neopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)copy SMILES
Affinity DataEC50:  100nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM429505(Remdesivir | US20240034730, Compound Remdesivir | ...)copy SMILEScopy InChI
Affinity DataEC50:  147nMMore data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648430(US20240033256, Compound 5)copy SMILES
Affinity DataEC50:  213nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476337(US10874687, Compound 1A)copy SMILEScopy InChI
Affinity DataEC50:  1.60E+3nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521548(Isopropyl ((((2S,3 S,4R,5R)-5-(4-aminopyrrolo[2, l...)copy SMILES
Affinity DataEC50:  1.70E+3nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM648431(US20240033256, Compound 6)copy SMILES
Affinity DataEC50:  1.89E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476337(US10874687, Compound 1A)copy SMILEScopy InChI
Affinity DataEC50:  2.00E+3nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476338(US10874687, Compound 1B)copy SMILEScopy InChI
Affinity DataEC50:  2.00E+3nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476338(US10874687, Compound 1B)copy SMILEScopy InChI
Affinity DataEC50:  2.20E+3nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521552(US11149049, No. 10)copy SMILES
Affinity DataEC50:  2.30E+3nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521547(Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)copy SMILES
Affinity DataEC50:  2.53E+4nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM521553(Isopropyl ((((2R,3 S,4R,5R)-5-(4-aminopyrrolo[2,1-...)copy SMILES
Affinity DataEC50: >5.00E+4nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P63PGUS Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476339(US10874687, Sofosbuvir)copy SMILES
Affinity DataEC50: >1.00E+5nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)TBA
LigandPNGBDBM476339(US10874687, Sofosbuvir)copy SMILES
Affinity DataEC50: >1.00E+5nMAssay Description:Compound activity against coronavirus was based on inhibition of virus induced cytopathogenicity acutely infected with a multiplicity of infection (m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B9238US Patent