Compile Data Set for Download or QSAR
Found 204 of ic50 for UniProtKB: P23458
LigandPNGBDBM50519523(CHEMBL4440718)copy SMILEScopy InChI
Affinity DataIC50: 0.530nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519523(CHEMBL4440718)copy SMILEScopy InChI
Affinity DataIC50: 0.530nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530395(CHEMBL4444178)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530395(CHEMBL4444178)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519518(CHEMBL4557190)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519537(CHEMBL4469750)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519543(CHEMBL4457060)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)copy SMILES
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR523SPubMed
LigandPNGBDBM50519542(CHEMBL4572855)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519520(CHEMBL4571117)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519519(CHEMBL4566158)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519538(CHEMBL4580625)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519532(CHEMBL4443834)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519536(CHEMBL4559585)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519539(CHEMBL4476261)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519535(CHEMBL4565054)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519548(CHEMBL4543984)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2/JAK1 in human PBMC assessed as reduction in IFNalpha-induced STAT1 phosphorylation preincubated for 5 mins followed by IFNalpha st...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HSHPubMed
LigandPNGBDBM50519534(CHEMBL4435079)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in INFalpha-induced Stat1 phosphorylation in CD3+CD4+ cells preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7F2WPubMed
LigandPNGBDBM50530400(CHEMBL4548200)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530400(CHEMBL4548200)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519531(CHEMBL4474729)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50583442(CHEMBL5077096)copy SMILES
Affinity DataIC50: 22nMAssay Description:Inhibition of TYK2/JAK1 signalling in human PBMC assessed as inhibition of INF-alpha stimulated phosphorylation of STAT3 preincubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GQCPubMed
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
LigandPNGBDBM50519529(CHEMBL4441840)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as inhibition of IFN-alpha-induced STAT-3 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z3XPubMed
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DTWPubMed
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM50519528(CHEMBL4537259)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519524(CHEMBL4587924)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as inhibition of IFN-alpha-induced STAT-3 phosphorylation preincubated for 45 mins followed by ...More data for this Ligand-Target Pair
LigandPNGBDBM50530383(CHEMBL4530719)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530383(CHEMBL4530719)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530394(CHEMBL4561663)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530394(CHEMBL4561663)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM387824(N-(2-Cyano-2-methylpropyl)-2-(1-((1r,4r)-4-(cyanom...)copy SMILES
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135FNPubMed
LigandPNGBDBM50519540(CHEMBL4468025)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50529618(CHEMBL4526032)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C507FPubMed
LigandPNGBDBM50519522(CHEMBL4578980)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50529618(CHEMBL4526032)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C507FPubMed
LigandPNGBDBM50530391(CHEMBL4444169)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530391(CHEMBL4444169)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM305821((1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubated for 45 mins ...More data for this Ligand-Target Pair
LigandPNGBDBM387818(2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihyd...)copy SMILES
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135FNPubMed
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