TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 5.40nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 9.5nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 10.1nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 13.9nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 23.3nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 26.4nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 57.7nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 66.6nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 79nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 228nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 397nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
MERCK SHARP & DOHME CORP.
US Patent
MERCK SHARP & DOHME CORP.
US Patent
Affinity DataIC50: 421nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
