Compile Data Set for Download or QSAR
Found 46 of ic50 for UniProtKB: P00533
LigandPNGBDBM537926(US11248003, Example 1)copy SMILES
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8PWWUS Patent
LigandPNGBDBM547941(WO2022090481, Example I-162)copy SMILES
Affinity DataIC50: 1.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
LigandPNGBDBM547965(WO2022090481, Example I-186)copy SMILES
Affinity DataIC50: 2.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
LigandPNGBDBM547940(WO2022090481, Example I-161)copy SMILES
Affinity DataIC50: 3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM547983(WO2022090481, Example I-204)copy SMILES
Affinity DataIC50: 3.5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)copy SMILES
Affinity DataIC50: 5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM625598(US20230322822, Compound 14)copy SMILES
Affinity DataIC50: 5.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM547888(WO2022090481, Example I-107)copy SMILES
Affinity DataIC50: 7.07nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed
LigandPNGBDBM625597(US20230322822, Compound 12)copy SMILES
Affinity DataIC50: 9.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625600(US20230322822, Compound 32)copy SMILES
Affinity DataIC50: 10.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625596(US20230322822, Compound 11)copy SMILES
Affinity DataIC50: 10.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625592(US20230322822, Compound 2)copy SMILES
Affinity DataIC50: 13.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625591(US20230322822, Compound 1)copy SMILES
Affinity DataIC50: 19.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625597(US20230322822, Compound 12)copy SMILES
Affinity DataIC50: 29.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625594(US20230322822, Compound 6)copy SMILES
Affinity DataIC50: 33.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625591(US20230322822, Compound 1)copy SMILES
Affinity DataIC50: 39.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625599(US20230322822, Compound 24)copy SMILES
Affinity DataIC50: 41.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625599(US20230322822, Compound 24)copy SMILES
Affinity DataIC50: 41.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625595(US20230322822, Compound 9)copy SMILES
Affinity DataIC50: 41.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625598(US20230322822, Compound 14)copy SMILES
Affinity DataIC50: 43.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625592(US20230322822, Compound 2)copy SMILES
Affinity DataIC50: 48.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625593(US20230322822, Compound 5)copy SMILES
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625594(US20230322822, Compound 6)copy SMILES
Affinity DataIC50: 51nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625600(US20230322822, Compound 32)copy SMILES
Affinity DataIC50: 51.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625610(US20230322822, Compound 30)copy SMILES
Affinity DataIC50: 55.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625609(US20230322822, Compound 29)copy SMILES
Affinity DataIC50: 57.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625605(US20230322822, Compound 13)copy SMILES
Affinity DataIC50: 60.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625596(US20230322822, Compound 11)copy SMILES
Affinity DataIC50: 66.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625593(US20230322822, Compound 5)copy SMILES
Affinity DataIC50: 73.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625606(US20230322822, Compound 23)copy SMILES
Affinity DataIC50: 79.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625604(US20230322822, Compound 4)copy SMILES
Affinity DataIC50: 80.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625608(US20230322822, Compound 28)copy SMILES
Affinity DataIC50: 85.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50185235(CHEMBL3823836 | US20230322822, Control compound 2)copy SMILEScopy InChI
Affinity DataIC50: 177nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)copy SMILEScopy InChI
Affinity DataIC50: 178nMMore data for this Ligand-Target Pair
LigandPNGBDBM625601(US20230322822, Control compound 1)copy SMILES
Affinity DataIC50: 184nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625603(US20230322822, Control compound 3)copy SMILES
Affinity DataIC50: 203nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625601(US20230322822, Control compound 1)copy SMILES
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM625603(US20230322822, Control compound 3)copy SMILES
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50185235(CHEMBL3823836 | US20230322822, Control compound 2)copy SMILEScopy InChI
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)copy SMILEScopy InChI
Affinity DataIC50: 513nMMore data for this Ligand-Target Pair
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)copy SMILEScopy InChI
Affinity DataIC50: 626nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
LigandPNGBDBM50160870(CHEMBL3787344 | US11896597, Compound EGF816 | WO20...)copy SMILEScopy InChI
Affinity DataIC50: 745nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765JH3PubMed