Affinity DataIC50: 2.20nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25M6604PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25M6604PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 7nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 14.4nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 17nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -11.2kcal/mole IC50: 50nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of Staphylococcus aureus wild type recombinant DHFR by MTS assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25M6604PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25M6604PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 61nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
