Compile Data Set for Download or QSAR
Found 27 of ic50 for UniProtKB: P54577
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18128((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097749(CHEMBL163375 | [2-Amino-3-((S)-4-hydroxy-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V1QPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091497((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4Q5GPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091497((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KR1PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18128((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4Q5GPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097746((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KR1PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104311((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097748(CHEMBL351127 | [2-Amino-3-((S)-4-hydroxy-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V1QPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18132((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V1QPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091496((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4Q5GPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097744((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KR1PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097744((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V1QPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104310((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 124nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097747(CHEMBL162552 | [2-Amino-3-((S)-4-hydroxy-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V1QPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104313((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 245nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097745(CHEMBL159436 | [2-Amino-3-((S)-4-hydroxy-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KR1PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081838(CHEMBL318019 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 510nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081839(CHEMBL98455 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-pr...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081834((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081837(CHEMBL99347 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-pr...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104314((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104312((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89BPKPubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081841(CHEMBL95581 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-pr...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081840((S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081836(CHEMBL95616 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-pr...)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081835((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XX9PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18128((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from mammalian cells was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4Q5GPubMed