BindingDB PrimarySearch

Found 13 of ic50 for UniProtKB: P15735

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 0.100nMAssay Description:Inhibition of PHKgamma2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q23J3DWTPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 0.336nMAssay Description:Inhibition of human PHKgamma2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 0.490nMAssay Description:Inhibition of PHKg2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2CV4M86PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI

IC50: 0.620nMAssay Description:Inhibition of human PHKgamma2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50392791(CHEMBL2151321 | US8486966, 1)copy SMILEScopy InChI

IC50: 6.10nMAssay Description:Inhibition of PhKg2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2GH9K2GPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)copy SMILEScopy InChI

IC50: 226nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PHKG2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Similars

Details Article
BindingDB Entry DOI: 10.7270/Q29888Z2PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50462709(CHEMBL4245507)copy SMILEScopy InChI

IC50: 1.00E+3nMAssay Description:Inhibition of PHK-gamma2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

Details Article
BindingDB Entry DOI: 10.7270/Q2XP77MHPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50499634(CHEMBL3741589)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of PHKG2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid

Details Article
BindingDB Entry DOI: 10.7270/Q2PZ5CV4PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50135286(CHEMBL3745885)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of human PHKg2 using [KKLNRTLSFAEPG] as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50401152(CHEMBL2205766)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of PHKG2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2HQ412BPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of PHKgamma2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2NC61NHPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50359359(CHEMBL1929238)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of PHKgamma2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2NC61NHPubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL

BDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)copy SMILEScopy InChI

IC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PHKG2 expressed in baculovirus expression system using serine/threonine-7 peptide a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details Article
BindingDB Entry DOI: 10.7270/Q2HM5CZGPubMed

Targets 1 ▿
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 13
Publications 11 ▿
- Bioorg Med Chem Lett 21: 7155-65 (2011) 2
- ACS Med Chem Lett 3: 705-709 (2012) 1
- J Med Chem 52: 3191-204 (2009) 1
- Eur J Med Chem 161: 456-467 (2019) 1
- Bioorg Med Chem 24: 521-44 (2016) 1
- Bioorg Med Chem Lett 22: 4613-8 (2012) 1
- J Med Chem 58: 9154-70 (2015) 1
- Bioorg Med Chem Lett 30: (2020) 1
- Bioorg Med Chem Lett 26: 5947-5950 (2016) 1
- Eur J Med Chem 141: 657-675 (2017) 1
- Bioorg Med Chem Lett 28: 2616-2621 (2018) 1
Institutions 11 ▿
- [Ansaris] 2
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
- [TBA, Takeda California, Inc., University of Florida, Merck & Co., AbbVie Bioresearch Center, Korea Institute of Science and Technology (KIST), National Cancer Institute, Vertex Pharmaceuticals, Inc, Icahn School of Medicine at Mount Sinai, Cellzome Ltd] 1
Affinity: 0.10 to 1.0E+5 nM▿
- IC50 13
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 6