Compile Data Set for Download or QSAR
Found 39 of ic50 for UniProtKB: P09483
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataIC50: 1.65nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50143313((12S,13aS)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Blockade of Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H3VPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296730(CHEMBL563848 | phenyl 1,4-diazabicyclo[3.2.2]nonan...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296728(3-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.07E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296729(4-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.78E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296747(3-benzoyl-4-bromophenyl 1,4-diazabicyclo[3.2.2]non...)copy SMILEScopy InChI
Affinity DataIC50: 2.04E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296717(3-benzoylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 2.62E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296726(3-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.51E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296724(3-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carb...)copy SMILEScopy InChI
Affinity DataIC50: 3.94E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296745(3,4-dichlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4...)copy SMILEScopy InChI
Affinity DataIC50: 4.98E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296753(4-(pyridin-2-yl)phenyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296752(4-(pyridin-3-yl)phenyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296751(4-(pyridin-4-yl)phenyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296720(4-methoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296727(4-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296725(2-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296723(2-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carb...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296722(CHEMBL554169 | p-tolyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296721(CHEMBL550054 | m-tolyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296719(3-methoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296718(4-benzoylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296716(CHEMBL564816 | biphenyl-4-yl 1,4-diazabicyclo[3.2....)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296714(4-phenoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 5.03E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296746(4-chloro-3-fluorophenyl 1,4-diazabicyclo[3.2.2]non...)copy SMILEScopy InChI
Affinity DataIC50: 6.98E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296743(4-bromo-3-chlorophenyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 7.12E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296744(4-bromo-3-methylphenyl 1,4-diazabicyclo[3.2.2]nona...)copy SMILEScopy InChI
Affinity DataIC50: 7.22E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296748(CHEMBL564850 | naphthalen-2-yl 1,4-diazabicyclo[3....)copy SMILEScopy InChI
Affinity DataIC50: 9.88E+3nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296741(1,5-diazabicyclo[4.2.2]decane carbamate | CHEMBL55...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296715(CHEMBL552005 | biphenyl-3-yl 1,4-diazabicyclo[3.2....)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296713(3-phenoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296740(1,4-diazabicyclo[4.2.2]decanecarbamate | CHEMBL563...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296739(1-(4-bromophenyl)-4-methyl-1,4-diazepane-1-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296738((R)-4-bromophenyl 3-methylpiperazine-1-carboxylate...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296737((3S,5R)-4-bromophenyl 3,5-dimethylpiperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50296736((2S,5R)-4-bromophenyl 2,5-dimethylpiperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0N69PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+4nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in acute hippocampal slicesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H3VPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 1.39E+5nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in CA1 stratum radiatum interneuronsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H3VPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+5nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in CA1 stratum radiatum interneuronsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H3VPubMed