Compile Data Set for Download or QSAR
Found 28 of ic50 for UniProtKB: P06612
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)copy SMILEScopy InChI
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)copy SMILEScopy InChI
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)copy SMILEScopy InChI
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)copy SMILEScopy InChI
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379468(US10266550, Compound 11c)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379475(US10266550, Compound 11j)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379478(US10266550, Compound 15a)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379474(US10266550, Compound 11i)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379465(US10266550, Compound 10b)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379471(US10266550, Compound 11f)copy SMILEScopy InChI
Affinity DataIC50: 5.85E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379477(US10266550, Compound 12)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379123(Ethyl 5,6-difluoro-9-nitro-3-oxo-3H-pyrido[3,2,1-k...)copy SMILEScopy InChI
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379458(5, 6-Difluoro-9-nitro-3-oxo-3H-pyrido[3, 2,1-kl]ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379461(US10266550, Compound 7d)copy SMILEScopy InChI
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379476(US10266550, Compound 11k)copy SMILEScopy InChI
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM50259213(CHEMBL4079855 | US10266550, Compound 7e)copy SMILEScopy InChI
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379459(9-Cyano-5, 6-d fluoro-3-oxo-3H-pyrido[3, 2, 1-d]ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379133(Ethyl 9-cyano-5, 6-difluoro-3-oxo-3H-pyrido[3, 2, ...)copy SMILEScopy InChI
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379134(Ethyl 5, 6-difluoro-3-oxo-9-(trifluoromethyl)-3H-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.25E+5nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
University of Bath

LigandPNGBDBM379460(US10266550, Compound 7c)copy SMILEScopy InChI
Affinity DataIC50: 1.25E+5nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H997HDUS Patent