Compile Data Set for Download or QSAR
Found 76 of ic50 for UniProtKB: P36897
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412768(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-methylpyrid...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412735(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412743(N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412766(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412738(2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...)copy SMILEScopy InChI
Affinity DataIC50: 0.420nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412739(2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 0.530nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412745(N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPurchaseMCE
PDB
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412773(N-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412775(3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412746(2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyrid...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412747(2-(6-(difluoromethyl)pyridin-2-yl)-4-(1H-pyrrolo[3...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412774(3-(trifluoromethyl)-N-{2-[6-(trifluoromethyl)pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412755(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412734(N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412751(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 0.710nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412759(N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 0.740nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412778(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)copy SMILEScopy InChI
Affinity DataIC50: 0.75nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412741(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412752(US10399987, Example 17 | methyl (4-((2-(6-(difluor...)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412764(N-(4-((2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 0.770nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412767(2-morpholino-N-(4-((2-(6-(trifluoromethyl)pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.770nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412736(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 0.780nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412781(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412762(3-methyl-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.850nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412772(3-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...)copy SMILEScopy InChI
Affinity DataIC50: 0.870nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412776(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 0.870nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412756(N-(4-((2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412749(2-(5-fluoropyridin-2-yl)-N-(3-fluoropyridin-4-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.910nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412757(N-(4-((2-(6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]p...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412780(N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412744(2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412753(N-(5-fluoro-4-((2-(5-fluoro-6-methylpyridin-2-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412770(1-(((2-(6-(difluoromethyl)pyridin-2-yl)-4-((3-fluo...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412782(N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412760(N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412777(3-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412771(N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412784(N-(6-{4-[(3-chloropyridin-4-yl)amino]-7H-pyrrolo[2...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412765(US10399987, Example 30 | methyl (4-((2-(6-(trifluo...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412779(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412761(3,3-dimethyl-N-(4-((2-(6-(trifluoromethyl)pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412742(2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412748(N-(2-chloro-5-fluoropyridin-4-yl)-2-(5-fluoro-6-me...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412783(N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412769(N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412758(N-(4-((2-(5-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM412754(1-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222X4NUS Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM21506(Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)copy SMILEScopy InChI
Affinity DataIC50: 33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb Company

US Patent
LigandPNGBDBM21510(Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
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