Affinity DataKd: 2.5nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataKd: 5.60nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nM Kd: 6.90nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataKd: 31nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 73nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 117nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 117nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Average Binding Constant for FGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 242nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged FGFR2 (unknown origin) (399 to 821 residues) expressed in baculovirus infected Sf9 ins...More data for this Ligand-Target Pair
Affinity DataKd: 250nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 350nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 361nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged FGFR2 (unknown origin) (399 to 821 residues) expressed in baculovirus infected Sf9 ins...More data for this Ligand-Target Pair
Affinity DataKd: 410nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 410nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 410nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 470nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Average Binding Constant for FGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding affinity to FGFR2More data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 660nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 660nMAssay Description:Binding affinity to FGFR2More data for this Ligand-Target Pair
Affinity DataKd: 674nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 674nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 680nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 680nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 790nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 790nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 790nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair