TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Antagonist activity against human TRPM8 by single cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 119nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 123nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 124nMAssay Description:Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 145nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 153nMAssay Description:Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 173nMAssay Description:Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 181nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 184nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 199nMAssay Description:Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 202nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 205nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 205nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 216nMAssay Description:Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 244nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 264nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 276nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 279nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 292nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 299nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 307nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 321nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 324nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 325nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 328nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 372nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 427nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 446nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 465nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 505nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 517nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 552nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 556nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 616nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 658nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.
Curated by ChEMBL
Affinity DataIC50: 677nMAssay Description:Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
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