Affinity DataIC50: 1.50E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 2.23E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 2.57E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 4.71E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 6.16E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at rat mGluR1 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 3.70E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 4.90E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 5.70E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 5.80E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 6.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 6.40E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in CHO cells assessed as inhibition of L-glutamate-induced intracellular cAMP accumulation t...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Merz Pharmaceuticals GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair