Compile Data Set for Download or QSAR
Found 213 Enz. Inhib. hit(s) with all data for entry = 1025
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)copy SMILEScopy InChI
Affinity DataKi:  0.300nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8145(N-(3,5-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8138(N-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-{pyraz...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8144(N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8142(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{pyrazol...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8171(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{2-phenylpy...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8135(N-(2H-1,3-benzodioxol-5-yl)-4-{pyrazolo[1,5-a]pyri...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8130(N-(4-nitrophenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8129(4-[(4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8140(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-{pyrazolo...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8144(N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8129(4-[(4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8139(N-(3,4-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8137(N-(3,4-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8138(N-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-{pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8163(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpy...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8144(N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8147(3-(2-{[3-(Trifluoromethyl)phenyl]amino}-4-pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8163(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpy...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8162(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methy...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8176(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[2-(4-fluor...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8168(N-(3,4-difluorophenyl)-4-{2-phenylpyrazolo[1,5-a]p...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8160(4-(6-Methylpyrazolo[1,5-b]pyridazin-3-yl)-N-[3-(tr...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8137(N-(3,4-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8139(N-(3,4-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8166(N-phenyl-4-{2-phenylpyrazolo[1,5-a]pyridazin-3-yl}...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8169(N-(3,5-difluorophenyl)-4-{2-phenylpyrazolo[1,5-a]p...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8140(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-{pyrazolo...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8134(N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazi...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8141(N-(3,5-dimethoxycyclohexa-1,3-dien-1-yl)-4-{pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8167(4-{2-phenylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(tr...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8142(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{pyrazol...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8141(N-(3,5-dimethoxycyclohexa-1,3-dien-1-yl)-4-{pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8140(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-{pyrazolo...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8209(N-(3,4-difluorophenyl)-4-[2-(4-fluorophenyl)-6-met...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8147(3-(2-{[3-(Trifluoromethyl)phenyl]amino}-4-pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8210(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[2-(4-fluor...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8141(N-(3,5-dimethoxycyclohexa-1,3-dien-1-yl)-4-{pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8135(N-(2H-1,3-benzodioxol-5-yl)-4-{pyrazolo[1,5-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
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