Compile Data Set for Download or QSAR
Found 55 Enz. Inhib. hit(s) with all data for entry = 10821
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571410(US11440922, Example 27 | ethyl (4E)-4-[3-(3- cyano...)copy SMILES
Affinity DataKi:  0.640nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571399(US11440922, Example 19 | ethyl (4E)-4-[3-(2,5- dif...)copy SMILES
Affinity DataKi:  0.890nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571414((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)copy SMILES
Affinity DataKi:  0.990nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571398(US11440922, Example 18 | ethyl (4E)-4-[3-(4- chlor...)copy SMILES
Affinity DataKi:  1.01nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571415(US11440922, Example 40 | methyl (4E)-4-[3-(3- chlo...)copy SMILES
Affinity DataKi:  1.29nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571397(US11440922, Example 3 | ethyl (4E)-3,3-dimethyl-4-...)copy SMILES
Affinity DataKi:  1.47nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)copy SMILES
Affinity DataKi:  1.60nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571428(US11440922, Example 128 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataKi:  1.82nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571408(US11440922, Example 22 | ethyl (4E)-3,3-dimethyl-4...)copy SMILES
Affinity DataKi:  1.90nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)copy SMILES
Affinity DataKi:  1.91nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571411(US11440922, Example 28 | ethyl (4E)-4-{3-[3- (cyan...)copy SMILES
Affinity DataKi:  2.12nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571429(US11440922, Example 166 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataKi:  2.24nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571430(US11440922, Example 167 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataKi:  2.42nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571418(US11440922, Example 48 | ethyl (3E)-2,2-dimethyl-3...)copy SMILES
Affinity DataKi:  2.44nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571412(US11440922, Example 31 | ethyl (4E)-4-[3-(4- cyano...)copy SMILES
Affinity DataKi:  2.93nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571427((3-chlorophenyl){(4E)-4- [3-(4-fluorophenyl)prop-2...)copy SMILES
Affinity DataKi:  4.02nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571431((3-chlorophenyl){(4E)-4- [3-(3-hydroxyphenyl)prop-...)copy SMILES
Affinity DataKi:  7.35nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571416(US11440922, Example 43 | {(4E)-4-[3-(3- chlorophen...)copy SMILES
Affinity DataKi:  7.39nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571426((3-chlorophenyl){(4E)-4- {3-[3- (hydroxymethyl)phe...)copy SMILES
Affinity DataKi:  8.05nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571422(US11440922, Example 101 | ethyl (3E)-3-[3-(3- chlo...)copy SMILES
Affinity DataKi:  11.2nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571413(US11440922, Example 32 | ethyl (4E)-4-[3-(3-cyano-...)copy SMILES
Affinity DataKi:  16.1nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571421(US11440922, Example 91 | ethyl (3E)-3-[3-(4- chlor...)copy SMILES
Affinity DataKi:  16.3nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571424(2-methyl-6-[3-(2,2,6,6- tetramethylpiperidin-4- yl...)copy SMILES
Affinity DataKi:  26.9nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571409(US11440922, Example 25 | ethyl (4E)-4-[3-(4- metho...)copy SMILES
Affinity DataKi:  28.6nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571420(US11440922, Example 73 | ethyl (3E)-3-[3-(4- cyano...)copy SMILES
Affinity DataKi:  29.8nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571419(US11440922, Example 64 | methyl (3E)-2,2-dimethyl-...)copy SMILES
Affinity DataKi:  82.9nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571417((2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxyme...)copy SMILES
Affinity DataKi:  323nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571432(3-[(3E)-3-{1-[(2,5- dimethylfuran-3- yl)carbonyl]-...)copy SMILES
Affinity DataKi:  637nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571423((3-chlorophenyl)[(4E)-4- {[5-(3-chlorophenyl)-1H- ...)copy SMILES
Affinity DataKi:  932nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571418(US11440922, Example 48 | ethyl (3E)-2,2-dimethyl-3...)copy SMILES
Affinity DataIC50: 2.02nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571410(US11440922, Example 27 | ethyl (4E)-4-[3-(3- cyano...)copy SMILES
Affinity DataIC50: 8.60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571412(US11440922, Example 31 | ethyl (4E)-4-[3-(4- cyano...)copy SMILES
Affinity DataIC50: 13.5nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571415(US11440922, Example 40 | methyl (4E)-4-[3-(3- chlo...)copy SMILES
Affinity DataIC50: 18.2nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571421(US11440922, Example 91 | ethyl (3E)-3-[3-(4- chlor...)copy SMILES
Affinity DataIC50: 31.6nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571409(US11440922, Example 25 | ethyl (4E)-4-[3-(4- metho...)copy SMILES
Affinity DataIC50: 31.8nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571411(US11440922, Example 28 | ethyl (4E)-4-{3-[3- (cyan...)copy SMILES
Affinity DataIC50: 37.2nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571413(US11440922, Example 32 | ethyl (4E)-4-[3-(3-cyano-...)copy SMILES
Affinity DataIC50: 60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571422(US11440922, Example 101 | ethyl (3E)-3-[3-(3- chlo...)copy SMILES
Affinity DataIC50: 66.3nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571408(US11440922, Example 22 | ethyl (4E)-3,3-dimethyl-4...)copy SMILES
Affinity DataIC50: 66.3nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571430(US11440922, Example 167 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataEC50:  23nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571431((3-chlorophenyl){(4E)-4- [3-(3-hydroxyphenyl)prop-...)copy SMILES
Affinity DataEC50:  224nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571436(3-{(3E)-3-[1-(3- methoxybenzoyl)-3,3- dimethylpipe...)copy SMILES
Affinity DataEC50:  87.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571432(3-[(3E)-3-{1-[(2,5- dimethylfuran-3- yl)carbonyl]-...)copy SMILES
Affinity DataEC50:  291nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571429(US11440922, Example 166 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataEC50:  51.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571435(US11440922, Example 137 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataEC50:  268nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571428(US11440922, Example 128 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataEC50:  165nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571434(US11440922, Example 126 | {(4E)-4-[3-(3- chlorophe...)copy SMILES
Affinity DataEC50:  115nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571427((3-chlorophenyl){(4E)-4- [3-(4-fluorophenyl)prop-2...)copy SMILES
Affinity DataEC50:  38.6nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571426((3-chlorophenyl){(4E)-4- {3-[3- (hydroxymethyl)phe...)copy SMILES
Affinity DataEC50:  49.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)copy SMILES
Affinity DataEC50:  52.8nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9NGPUS Patent
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