Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for entry = 2065
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataKi:  26nM ΔG°:  -44.0kJ/molepH: 7.5 T: 2°CAssay Description:For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  659nM ΔG°:  -35.9kJ/molepH: 7.5 T: 2°CAssay Description:For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataKi:  8.58E+3nM ΔG°:  -29.4kJ/molepH: 7.5 T: 2°CAssay Description:For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 42nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 104nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 168nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 266nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 314nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 353nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 443nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 744nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 845nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 856nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 2.71E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 6.30E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 8.83E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.43E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.36E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed