Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for entry = 2378
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363473((S)-9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363475(9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363474((R)-9-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroiso...)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363472(US9850245, Example 6A)copy SMILEScopy InChI
Affinity DataIC50: 6.60nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363493(Typical Example for Hydroamination | US9850245, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363483(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363477(9-(2-(5-(1H-tetrazol-1- yl)pyrazin-2-yl)-2- hydrox...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363488(9-(2-hydroxy-2-(2-methyl-6-(1H- tetrazol-1-yl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363487((1R,2'R,5S)-8-((R)-2-hydroxy-2- (4-methyl-1-oxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 13.4nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363489(9-(2-(6-(1H-tetrazol-1- yl)pyridazin-3-yl)-2- hydr...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363492((R)-9-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisob...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363485(3-chloro-4-(9-(2-hydroxy-2-(2- methyl-6-(1H-tetraz...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363489(9-(2-(6-(1H-tetrazol-1- yl)pyridazin-3-yl)-2- hydr...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363245(US9850245, Example 2A)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363486((R)-9-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroiso...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363483(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363480(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363471(US9850245, Example 4A)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363491(9-(2-(2-(1H-tetrazol-1- yl)pyrimidin-5-yl)-2- hydr...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363478((R)-4-(9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363480(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363482((R)-5-(1-hydroxy-2-(4-(4-methyl- 5-oxo-2,5-dihydro...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363479((S)-4-(9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM363476((R)-8-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroiso...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J3NUS Patent