Compile Data Set for Download or QSAR
Found 79 Enz. Inhib. hit(s) with all data for entry = 50001775
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367855(CHEMBL4175929)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367737(CHEMBL4173631)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367857(CHEMBL4159417)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367857(CHEMBL4159417)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367955(CHEMBL4174716)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367873(CHEMBL4169139)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367957(CHEMBL4174715)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367685(CHEMBL4172363)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367707(CHEMBL4167916)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367845(CHEMBL4173254)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367684(CHEMBL4162567)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367955(CHEMBL4174716)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367919(CHEMBL4159594)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367840(CHEMBL4162954)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 195nMAssay Description:Inhibition of CDK12 in human SK-BR-3 cells assessed as reduction in RNA polymerase 2 Ser2 phosphorylation incubated for 4 hrs byMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367856(CHEMBL4166407)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367854(CHEMBL4164483)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)copy SMILEScopy InChI
Affinity DataIC50: 259nMAssay Description:Inhibition of CDK12 in human SK-BR-3 cells assessed as reduction in RNA polymerase 2 Ser2 phosphorylation incubated for 4 hrs byMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367679(CHEMBL4164064)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367737(CHEMBL4173631)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367843(CHEMBL4174324)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367919(CHEMBL4159594)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367683(CHEMBL4170884)copy SMILEScopy InChI
Affinity DataIC50: 640nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367874(CHEMBL4172525)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367856(CHEMBL4166407)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367855(CHEMBL4175929)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367683(CHEMBL4170884)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367840(CHEMBL4162954)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367843(CHEMBL4174324)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367956(CHEMBL4164065)copy SMILEScopy InChI
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367956(CHEMBL4164065)copy SMILEScopy InChI
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367737(CHEMBL4173631)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367849(CHEMBL4175774)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367737(CHEMBL4173631)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367849(CHEMBL4175774)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367849(CHEMBL4175774)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367854(CHEMBL4164483)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1G6FPubMed
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