Compile Data Set for Download or QSAR
Found 45 Enz. Inhib. hit(s) with all data for entry = 50001978
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451457(CHEMBL4210135)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451456(CHEMBL4215058)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451454(CHEMBL4207534)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451459(CHEMBL4208664)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451453(CHEMBL2325603)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451448(CHEMBL4213464)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451460(CHEMBL4215917)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 8 subunit alpha(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of rat Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451455(CHEMBL2325325)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451452(CHEMBL2321912)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451450(CHEMBL4208535)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells by voltage clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451449(CHEMBL4213602)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 309nMAssay Description:Inhibition of human Nav1.1 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human Nav1.4 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451450(CHEMBL4208535)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 4.01E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 4.25E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 6.17E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 6.44E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 8.83E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 11 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.9 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of human Nav1.5 by Q-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 2.52E+4nMAssay Description:Inhibition of human ERG by PatchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in HeLa cells assessed as increase in cAMP accumulation measured after 20 mins by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at recombinant human adenosine A1 receptor expressed in mouse BA/F3 cells assessed as increase in calcium flux by spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed