TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of inactivated state of mouse NaV1.7 assessed as decrease in sodium current amplitude at -60 mV holding potential after 20 mins by Qube384...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of full length human NaV1.7 expressed in HEK293 cells coexpressing Nav beta1 subunit assessed as decrease in sodium current amplitude by P...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of mouse NaV1.7 assessed as decrease in sodium current amplitude at -60 mV holding potential after 20 mins by Qube384...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 Y1537A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.6 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.5 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 Y1537A mutant expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.6 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 265nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.5 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 950nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.27E+3nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Xenon Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.5 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair