Compile Data Set for Download or QSAR
Found 42 Enz. Inhib. hit(s) with all data for entry = 50003089
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi: <0.0250nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi:  0.100nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50466801(CHEMBL4286522)copy SMILEScopy InChI
Affinity DataKi: <0.200nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50466801(CHEMBL4286522)copy SMILEScopy InChI
Affinity DataKi:  0.290nMAssay Description:Inhibition of L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50436850(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50436850(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataKi:  0.740nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataKi:  5.80nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)copy SMILEScopy InChI
Affinity DataKi:  8.20nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataKi:  8.20nMAssay Description:Inhibition of L1196M mutant (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi:  8.20nMAssay Description:Inhibition of L1196M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50436850(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)copy SMILEScopy InChI
Affinity DataKi:  230nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataKi:  330nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)copy SMILEScopy InChI
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)copy SMILEScopy InChI
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type EML4/ALK F1174L mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50466801(CHEMBL4286522)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of wild type EML4/ALK (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of wild type EML4/ALK (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild type EML4/ALK C1156Y mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild type EML4/ALK S1206Y mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of wild type EML4/ALK L1152R mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50466801(CHEMBL4286522)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type EML4/ALK L1196M mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type EML4/ALK G1269A mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of wild type EML4/ALK L1196M mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of wild type EML4/ALK 1151Tins mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of wild type EML4/ALK G1202R mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154KR2PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of wild type EML4/ALK (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 165nMAssay Description:Inhibition of wild type EML4/ALK F1174L mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 478nMAssay Description:Inhibition of wild type EML4/ALK C1156Y mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 605nMAssay Description:Inhibition of wild type EML4/ALK G1269A mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 626nMAssay Description:Inhibition of wild type EML4/ALK S1206Y mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 843nMAssay Description:Inhibition of wild type EML4/ALK L1196M mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of wild type EML4/ALK L1152R mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of wild type EML4/ALK G1202R mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Taibah University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of wild type EML4/ALK 1151Tins mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair