Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with all data for entry = 50006815
TargetDihydrofolate reductase(Mus musculus (Mouse))
State University of New York

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054213(3-(1-Carboxymethyl-1H-imidazol-4-yl)-2-{4-[(2,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054215(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMedDrugBank
TargetDihydrofolate reductase(Mus musculus (Mouse))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054214(2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-amin...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054213(3-(1-Carboxymethyl-1H-imidazol-4-yl)-2-{4-[(2,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054214(2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-amin...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50054215(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3K8HPubMed