Compile Data Set for Download or QSAR
Found 35 Enz. Inhib. hit(s) with all data for entry = 50007665
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066338(CHEMBL327115 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  0.610nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  0.740nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066340((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066339((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066341((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066335(CHEMBL111051 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)copy SMILEScopy InChI
Affinity DataKi:  7.00E+3nMAssay Description:Selectivity of the compound was evaluated as the binding affinity between thrombin versus trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  2.30E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  2.70E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  2.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  2.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  3.60E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  4.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)copy SMILEScopy InChI
Affinity DataKi: >5.00E+4nMAssay Description:Selectivity of the compound was evaluated as the binding affinity between thrombin versus ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  6.70E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  7.10E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  7.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasma kallikrein.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.13E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasmin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.31E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  1.52E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasmin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  1.74E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  2.44E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasmin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)copy SMILEScopy InChI
Affinity DataKi:  3.99E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasma kallikrein.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  5.86E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasma kallikrein.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  6.91E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasmin.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  8.16E+5nMAssay Description:Binding affinity of the compound was evaluated on serine protease plasma kallikrein.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7T4GPubMed