Compile Data Set for Download or QSAR
Found 14 Enz. Inhib. hit(s) with all data for entry = 50007732
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)copy SMILEScopy InChI
Affinity DataKi:  0.330nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)copy SMILEScopy InChI
Affinity DataKi:  0.710nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro15-1788 from recombinant human GABA-A alpha5beta3gamma2 receptor expressed in mouse L(tk-) cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inverse agonist activity at recombinant human GABA-A alpha5beta3gamma2 receptor expressed in mouse L(tk-) cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)copy SMILEScopy InChI
Affinity DataKi:  71nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)copy SMILEScopy InChI
Affinity DataKi:  280nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)copy SMILEScopy InChI
Affinity DataEC50:  1.40E+4nMAssay Description:Positive allosteric modulation of human GABA-A alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50361376(OXYPEUCEDANIN)copy SMILEScopy InChI
Affinity DataEC50:  2.50E+4nMAssay Description:Positive allosteric modulation of human GABA-A alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50512168(CHEMBL4464551)copy SMILEScopy InChI
Affinity DataEC50:  9.30E+3nMAssay Description:Positive allosteric modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes by two-electrode voltage c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125X0PPubMed