Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 0.990nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 8.40nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 9.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 3.90E+3nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 0.920nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataEC50: 1.18E+3nMAssay Description:Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assa...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
China State Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assa...More data for this Ligand-Target Pair