Compile Data Set for Download or QSAR
Found 33 Enz. Inhib. hit(s) with all data for entry = 50009452
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)copy SMILEScopy InChI
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529075(CHEMBL4544153)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529074(CHEMBL4574299)copy SMILEScopy InChI
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529069(CHEMBL4476294)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529074(CHEMBL4574299)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529071(CHEMBL4471208)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529069(CHEMBL4476294)copy SMILEScopy InChI
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529075(CHEMBL4544153)copy SMILEScopy InChI
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529071(CHEMBL4471208)copy SMILEScopy InChI
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)copy SMILEScopy InChI
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529073(CHEMBL4543789)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529072(CHEMBL4459410)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529073(CHEMBL4543789)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529072(CHEMBL4459410)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)copy SMILEScopy InChI
Affinity DataKi:  3.90E+3nMAssay Description:Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529070(CHEMBL4457939)copy SMILEScopy InChI
Affinity DataIC50: 0.920nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529069(CHEMBL4476294)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529075(CHEMBL4544153)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529079(CHEMBL4438415)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529073(CHEMBL4543789)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529071(CHEMBL4471208)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529076(CHEMBL4441488)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529077(CHEMBL4434876)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529078(CHEMBL4539622)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529072(CHEMBL4459410)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529074(CHEMBL4574299)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529077(CHEMBL4434876)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529077(CHEMBL4434876)copy SMILEScopy InChI
Affinity DataEC50:  1.18E+3nMAssay Description:Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2ZZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)copy SMILEScopy InChI
Affinity DataEC50:  18nMAssay Description:Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assa...More data for this Ligand-Target Pair