Compile Data Set for Download or QSAR
Found 27 Enz. Inhib. hit(s) with all data for entry = 50010526
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539761(CHEMBL4648852)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539762(CHEMBL4632935)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539765(CHEMBL4640636)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539760(CHEMBL4636611)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation incubated for 24 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539759(CHEMBL4646899)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539766(CHEMBL4645376)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539754(CHEMBL4648671)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539753(CHEMBL4648056)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539757(CHEMBL4648124)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539758(CHEMBL4640234)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50507447(CHEMBL4456598)copy SMILEScopy InChI
Affinity DataIC50: 142nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539747(CHEMBL4645768)copy SMILEScopy InChI
Affinity DataIC50: 254nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539746(CHEMBL4642659)copy SMILEScopy InChI
Affinity DataIC50: 351nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539755(CHEMBL4649703)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539744(CHEMBL4637314)copy SMILEScopy InChI
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539745(CHEMBL4642347)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539743(CHEMBL4637434)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539756(CHEMBL4639210)copy SMILEScopy InChI
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539748(CHEMBL4647242)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539750(CHEMBL4649174)copy SMILEScopy InChI
Affinity DataIC50: 4.53E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539749(CHEMBL4643600)copy SMILEScopy InChI
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539752(CHEMBL4638484)copy SMILEScopy InChI
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539764(CHEMBL4635454)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539751(CHEMBL4649393)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed