Compile Data Set for Download or QSAR
Found 25 Enz. Inhib. hit(s) with all data for entry = 50010656
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)copy SMILEScopy InChI
Affinity DataIC50: 101nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)copy SMILEScopy InChI
Affinity DataIC50: 142nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)copy SMILEScopy InChI
Affinity DataIC50: 204nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 218nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)copy SMILEScopy InChI
Affinity DataIC50: 226nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 231nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)copy SMILEScopy InChI
Affinity DataIC50: 369nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)copy SMILEScopy InChI
Affinity DataIC50: 426nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540859(CHEMBL4632904)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540860(CHEMBL4645423)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataKd:  3.19E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)copy SMILEScopy InChI
Affinity DataKd:  156nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataKd:  21nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)copy SMILEScopy InChI
Affinity DataKd:  2.43E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93K8PubMed