Compile Data Set for Download or QSAR
Found 41 Enz. Inhib. hit(s) with all data for entry = 50011190
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 144nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 367nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 442nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50545548(CHEMBL4633247)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.53E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.63E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50075373(1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...)copy SMILEScopy InChI
Affinity DataIC50: 7.83E+3nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 1 uM by measurin...More data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50001285((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.95E+4nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.93E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 5.36E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 5.65E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.67E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 9.49E+4nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 0.5 uM by measur...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+5nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 3 uM by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+5nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 1 uM by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+5nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 2 uM by measurin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)copy SMILEScopy InChI
Affinity DataEC50:  1.40E+4nMAssay Description:Modulation of ABCG2 (unknown origin) expressed in High Five insect cell vesicle membrane assessed as stimulation of ATPase activity after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2ZQPPubMed