Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for entry = 50012990
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300973(2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...)copy SMILES
Affinity DataIC50: 0.0501nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300967(5-Fluoro-6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-tri...)copy SMILES
Affinity DataIC50: 0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM301005(5-fluoro-N-(1- (3- fluoropropyl) azetidin-3-yl)-6-...)copy SMILES
Affinity DataIC50: 0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300969(BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...)copy SMILES
Affinity DataIC50: 0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561995(CHEMBL4789498)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300963(2-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300964(5-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...)copy SMILES
Affinity DataIC50: 0.251nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 0.316nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300985(6-((6S,8S)-7- (2,2- difluoroethyl)- 8- (difluorome...)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561995(CHEMBL4789498)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300973(2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...)copy SMILES
Affinity DataIC50: 1nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300967(5-Fluoro-6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-tri...)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300963(2-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...)copy SMILES
Affinity DataIC50: 1.60nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300964(5-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...)copy SMILES
Affinity DataIC50: 2nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM301005(5-fluoro-N-(1- (3- fluoropropyl) azetidin-3-yl)-6-...)copy SMILES
Affinity DataIC50: 2nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300985(6-((6S,8S)-7- (2,2- difluoroethyl)- 8- (difluorome...)copy SMILES
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561997(CHEMBL4757584)copy SMILES
Affinity DataIC50: 2.5nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300969(BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...)copy SMILES
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 4nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561996(CHEMBL4745941)copy SMILES
Affinity DataIC50: 5nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561996(CHEMBL4745941)copy SMILES
Affinity DataIC50: 16nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561998(CHEMBL4746365)copy SMILES
Affinity DataIC50: 40nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561998(CHEMBL4746365)copy SMILES
Affinity DataIC50: 126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50561997(CHEMBL4757584)copy SMILES
Affinity DataIC50: 501nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80PDPubMed