Compile Data Set for Download or QSAR
Found 20 Enz. Inhib. hit(s) with all data for entry = 50014569
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144624((5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-pipera...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM22890(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144626(CHEMBL305662 | [4-((2S,5S)-5-{4-[(R)-(4-Chloro-phe...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144625(1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-p...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144627(CHEMBL74688 | [4-((2R,5R)-5-{4-[(R)-(4-Chloro-phen...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144622(CHEMBL312082 | [3-(5-{4-[(R)-(4-Chloro-phenyl)-phe...)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144620(CHEMBL73706 | [4-(5-{4-[Bis-(4-fluoro-phenyl)-meth...)copy SMILEScopy InChI
Affinity DataKi:  550nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144623(CHEMBL74779 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phen...)copy SMILEScopy InChI
Affinity DataKi:  660nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144621(CHEMBL73148 | CMI-977 | N-(4-{(2S,5S)-5-[(4-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 117nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144623(CHEMBL74779 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phen...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50029781((R)-(+)-N-{3-[5-(4-fluorobenzyl)thien-2-yl]-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144620(CHEMBL73706 | [4-(5-{4-[Bis-(4-fluoro-phenyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144625(1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-p...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in an RBL-2H3 cell lysateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144620(CHEMBL73706 | [4-(5-{4-[Bis-(4-fluoro-phenyl)-meth...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in an RBL-2H3 cell lysateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144626(CHEMBL305662 | [4-((2S,5S)-5-{4-[(R)-(4-Chloro-phe...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144625(1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-p...)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144627(CHEMBL74688 | [4-((2R,5R)-5-{4-[(R)-(4-Chloro-phen...)copy SMILEScopy InChI
Affinity DataIC50: 510nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)copy SMILEScopy InChI
Affinity DataIC50: 873nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMedDrugBank
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144624((5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-pipera...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
UCB Research

Curated by ChEMBL
LigandPNGBDBM50144622(CHEMBL312082 | [3-(5-{4-[(R)-(4-Chloro-phenyl)-phe...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7G2PPubMed