Compile Data Set for Download or QSAR
Found 71 Enz. Inhib. hit(s) with all data for entry = 50014941
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human TRKB using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate in presence of ATP by radiometric HotSpot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMAssay Description:Inhibition of human TRKA using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of TrkA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human wild type ALK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 2.10nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 2.30nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 2.40nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of TrkB (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 3.5nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 4.90nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkC (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of ALK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 9.40nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))TBA
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of ROS1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581357(CHEMBL5093999)copy SMILES
Affinity DataIC50: 19nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581362(CHEMBL5091992)copy SMILES
Affinity DataIC50: 68nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581355(CHEMBL5070835)copy SMILES
Affinity DataIC50: 89nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50581356(CHEMBL5080010)copy SMILES
Affinity DataIC50: 182nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)copy SMILEScopy InChI
Affinity DataIC50: 274nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6H3KPubMed
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