Compile Data Set for Download or QSAR
Found 33 Enz. Inhib. hit(s) with all data for entry = 50015413
LigandPNGBDBM50469035(CHEMBL4282693)copy SMILEScopy InChI
Affinity DataKi:  440nMAssay Description:Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50430584(CHEMBL2337806)copy SMILEScopy InChI
Affinity DataKi:  440nMAssay Description:Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586357(CHEMBL5080660)copy SMILES
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586355(CHEMBL5087243)copy SMILES
Affinity DataIC50: 23nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586354(CHEMBL5078323)copy SMILES
Affinity DataIC50: 27nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586353(CHEMBL5092991)copy SMILES
Affinity DataIC50: 29nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586357(CHEMBL5080660)copy SMILES
Affinity DataIC50: 31nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586356(CHEMBL5081948)copy SMILES
Affinity DataIC50: 61nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50511342(CHEMBL4538474)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibition of SHIP2 in serum-starved mouse Mm1 cells assessed as reduction in Akt phosphorylation incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586355(CHEMBL5087243)copy SMILES
Affinity DataIC50: 700nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586354(CHEMBL5078323)copy SMILES
Affinity DataIC50: 900nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586355(CHEMBL5087243)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50430584(CHEMBL2337806)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586358(CHEMBL5092487)copy SMILES
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586354(CHEMBL5078323)copy SMILES
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM114257(3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-q...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50075651(1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosph...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586356(CHEMBL5081948)copy SMILES
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM114257(3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-q...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586357(CHEMBL5080660)copy SMILES
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586353(CHEMBL5092991)copy SMILES
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586353(CHEMBL5092991)copy SMILES
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50088360(2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM61867(2-(4-hydroxyphenyl)-5,6,7,8-tetrakis(oxidanyl)chro...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50511343(CHEMBL4473747)copy SMILEScopy InChI
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50088360(2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586357(CHEMBL5080660)copy SMILES
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50586356(CHEMBL5081948)copy SMILES
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50333645(CHEMBL1756 | Estramustine phosphate)copy SMILEScopy InChI
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50333645(CHEMBL1756 | Estramustine phosphate)copy SMILEScopy InChI
Affinity DataIC50: 4.17E+4nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50088360(2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed
LigandPNGBDBM50586359(CHEMBL5094588)copy SMILES
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CZMPubMed