Compile Data Set for Download or QSAR
Found 23 Enz. Inhib. hit(s) with all data for entry = 50016043
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164242(6-(5-Phenyl-2-piperidin-4-yl-3H-imidazol-4-yl)-1-(...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164228(1-(isopropylsulfonyl)-6-(4-phenyl-1H-imidazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164240(6-[5-(4-Fluoro-phenyl)-3H-imidazol-4-yl]-1-(propan...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164236(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164230(6-[5-(4-Fluoro-phenyl)-2-isopropyl-3H-imidazol-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164239(6-[2-Ethyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164229(6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164232(6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164231(6-[2-(1-Isobutyl-piperidin-4-yl)-5-phenyl-3H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164232(6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164233(6-(2-(2,6-dichlorophenyl)-4-phenyl-1H-imidazol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 15.3nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164235(6-[2-tert-Butyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)copy SMILEScopy InChI
Affinity DataIC50: 15.9nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164234(1-Cyclopentanesulfonyl-6-[2-(2,6-difluoro-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164238(6-[5-(4-Fluoro-phenyl)-3-methyl-3H-imidazol-4-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 20.7nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164237(2-Amino-6-[2-(2,6-difluoro-phenyl)-5-phenyl-3H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 22.8nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164241(6-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164240(6-[5-(4-Fluoro-phenyl)-3H-imidazol-4-yl]-1-(propan...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164228(1-(isopropylsulfonyl)-6-(4-phenyl-1H-imidazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164239(6-[2-Ethyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164231(6-[2-(1-Isobutyl-piperidin-4-yl)-5-phenyl-3H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+3nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164230(6-[5-(4-Fluoro-phenyl)-2-isopropyl-3H-imidazol-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164234(1-Cyclopentanesulfonyl-6-[2-(2,6-difluoro-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly and Co.

Curated by ChEMBL
LigandPNGBDBM50164235(6-[2-tert-Butyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)copy SMILEScopy InChI
Affinity DataIC50: 3.18E+4nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90869PubMed