Compile Data Set for Download or QSAR
Found 38 Enz. Inhib. hit(s) with all data for entry = 50016421
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168776(3-(5-(2'-chloro-2-fluorobiphenyl-4-yl)-1-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168760(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methoxybiphen...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168785(3-(5-(2'-acetyl-2-fluorobiphenyl-4-yl)-1-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168770(3-(1-(4-chlorobenzyl)-5-(2,2'-difluorobiphenyl-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168782(3-(1-(4-chlorobenzyl)-5-(3-fluoro-4-(pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168768(3-(5-(biphenyl-4-yl)-1-(4-chlorobenzyl)-3-methyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168787(3-(1-(4-chlorobenzyl)-5-(2-chlorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168788(3-(1-(4-chlorobenzyl)-5-(2-fluoro-4'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168777(3-[1-(4-Chloro-benzyl)-5-(3-fluoro-4-pyrazin-2-yl-...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168763(3-(1-(4-chlorobenzyl)-5-(2-fluoro-3'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168762(3-[5-Biphenyl-3-yl-1-(4-chloro-benzyl)-3-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168771(3-[1-(4-Chloro-benzyl)-3-(3,3-dimethyl-butyryl)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168774(3-[3-(2-tert-Butylsulfanyl-acetyl)-1-(4-chloro-ben...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168765(3-[3-(4-tert-Butyl-benzyl)-1-(4-chloro-benzyl)-5-i...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168779(3-[5-tert-Butyl-1-(4-chloro-benzyl)-3-methyl-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168790(3-[1-(4-Chloro-benzyl)-3-methyl-5-phenyl-1H-indol-...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168769(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-phenoxy-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168781(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-(2-methyl-ben...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 950nMAssay Description:In vitro inhibition against human Thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition against recombinant human mPGES-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition against recombinant human mPGES-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168784(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-methyl-1H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition against human Thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168772(3-[1-(4-Chloro-benzyl)-5-fluoro-3-methyl-1H-indol-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168789(3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168764(3-[3-tert-Butylsulfanyl-5-isopropyl-1-(3-phenyl-pr...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168786(3-[1-(4-Chloro-benzyl)-7-isopropyl-3-methyl-1H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168775(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-phenyl-1H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168778(3-(1-Allyl-3-tert-butylsulfanyl-5-isopropyl-1H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168783(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-isop...)copy SMILEScopy InChI
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168767(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-isop...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168780(3-(3-tert-Butylsulfanyl-5-isopropyl-1-methyl-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168773(3-(3-tert-Butylsulfanyl-5-isopropyl-1H-indol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed