Compile Data Set for Download or QSAR
Found 39 Enz. Inhib. hit(s) with all data for entry = 50017635
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184818(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184822(CHEMBL383671 | methyl 4-(4-fluoro-2-methyl-1H-indo...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184812(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184817(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184811((R)-1-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184816(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyr...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184808((S)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184821(CHEMBL206545 | N-(3-(4-(4-fluoro-2-methyl-1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184820(CHEMBL205283 | methyl 5-methyl-4-(2-methyl-1H-indo...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184814(CHEMBL207842 | ethyl 4-(1H-indol-5-yloxy)-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184819(CHEMBL381104 | methyl 4-(1H-indol-5-yloxy)pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184810(CHEMBL377302 | ethyl 4-(1H-indol-5-yloxy)-5-ethylp...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184815(CHEMBL381973 | ethyl 4-(1H-indol-5-yloxy)-5-isopro...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184812(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184821(CHEMBL206545 | N-(3-(4-(4-fluoro-2-methyl-1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184818(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against LCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184817(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184808((S)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184811((R)-1-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against PKC alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against JAK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7H7NPubMed