Compile Data Set for Download or QSAR
Found 13 Enz. Inhib. hit(s) with all data for entry = 50018114
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))TBA
LigandPNGBDBM50404376(CHEMBL5273773)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))TBA
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50150812(CHEMBL3775853 | US10702504, Compound D)copy SMILEScopy InChI
Affinity DataIC50: 218nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase RNF114(Homo sapiens)TBA
LigandPNGBDBM50404380(CHEMBL5265809)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50404379(CHEMBL5184599)copy SMILEScopy InChI
Affinity DataIC50: 247nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50404377(CHEMBL5276376)copy SMILEScopy InChI
Affinity DataIC50: 338nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50404384(CHEMBL5269969)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase RNF4(Homo sapiens)TBA
LigandPNGBDBM50404382(CHEMBL5274757)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetProtein fem-1 homolog B(Homo sapiens)TBA
LigandPNGBDBM50404383(CHEMBL5269604)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase RNF4(Homo sapiens)TBA
LigandPNGBDBM50404381(CHEMBL5274740)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetProtein cereblon(Homo sapiens (Human))TBA
LigandPNGBDBM50404378(CHEMBL5275511)copy SMILEScopy InChI
Affinity DataEC50:  79nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50404375(CHEMBL5274307)copy SMILEScopy InChI
Affinity DataKd:  11nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetProtein cereblon(Homo sapiens (Human))TBA
LigandPNGBDBM50404379(CHEMBL5184599)copy SMILEScopy InChI
Affinity DataEC50:  703nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails