Compile Data Set for Download or QSAR
Found 38 Enz. Inhib. hit(s) with all data for entry = 50018227
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407493(CHEMBL5288446)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Relative potency against Histamine H1 receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407492(CHEMBL5280732)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407464(CHEMBL5289275)copy SMILEScopy InChI
Affinity DataKi:  2.41E+3nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407467(CHEMBL5289169)copy SMILEScopy InChI
Affinity DataKi:  3.12E+3nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407491(CHEMBL5282293)copy SMILEScopy InChI
Affinity DataKi:  3.80E+3nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407461(CHEMBL5274458)copy SMILEScopy InChI
Affinity DataKi:  4.46E+4nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407454(CHEMBL5281526)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407449(CHEMBL5285995)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA
LigandPNGBDBM50407495(CHEMBL5286471)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetDNA polymerase beta(Homo sapiens (Human))TBA
LigandPNGBDBM50407496(CHEMBL5284382)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407448(CHEMBL4454956)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50407495(CHEMBL5286471)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA
LigandPNGBDBM50407494(CHEMBL5276118)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407452(CHEMBL5284923)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50407494(CHEMBL5276118)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407454(CHEMBL5281526)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407450(CHEMBL4544901)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407451(CHEMBL5270628)copy SMILEScopy InChI
Affinity DataIC50: 188nMAssay Description:In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50407447(CHEMBL5285729)copy SMILEScopy InChI
Affinity DataIC50: 303nMAssay Description:Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407493(CHEMBL5288446)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))TBA
LigandPNGBDBM50136777(CHEMBL3753077)copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:Maximum response (E max) against Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
LigandPNGBDBM50407452(CHEMBL5284923)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407449(CHEMBL5285995)copy SMILEScopy InChI
Affinity DataIC50: 1.07E+3nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407492(CHEMBL5280732)copy SMILEScopy InChI
Affinity DataIC50: 1.09E+3nMAssay Description:Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407448(CHEMBL4454956)copy SMILEScopy InChI
Affinity DataIC50: 1.39E+3nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50136777(CHEMBL3753077)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407451(CHEMBL5270628)copy SMILEScopy InChI
Affinity DataIC50: 2.04E+3nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50552137(CHEMBL465158)copy SMILES
Affinity DataIC50: 6.58E+3nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407464(CHEMBL5289275)copy SMILEScopy InChI
Affinity DataIC50: 7.97E+3nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407467(CHEMBL5289169)copy SMILEScopy InChI
Affinity DataIC50: 1.01E+4nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407491(CHEMBL5282293)copy SMILEScopy InChI
Affinity DataIC50: 1.22E+4nMAssay Description:Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaMore data for this Ligand-Target Pair
In DepthDetails
TargetDNA polymerase beta(Homo sapiens (Human))TBA
LigandPNGBDBM50407500(CHEMBL5275313)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407450(CHEMBL4544901)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
Target7-dehydrocholesterol reductase(Homo sapiens (Human))TBA
LigandPNGBDBM50407447(CHEMBL5285729)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetDNA polymerase beta(Homo sapiens (Human))TBA
LigandPNGBDBM50407497(CHEMBL5270819)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetDNA polymerase beta(Homo sapiens (Human))TBA
LigandPNGBDBM50407498(CHEMBL5280798)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
TargetDNA polymerase beta(Homo sapiens (Human))TBA
LigandPNGBDBM50407499(CHEMBL5270153)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407461(CHEMBL5274458)copy SMILEScopy InChI
Affinity DataIC50: 1.35E+5nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails