Compile Data Set for Download or QSAR
Found 41 Enz. Inhib. hit(s) with all data for entry = 50018449
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195888(2-(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195877(3-(3-chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195892(3-(3-chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)p...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195884(3-(3-chloro-4-fluorophenyl)-7-(3,4,5-trimethoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195890(3-(4-chlorophenyl)-7-(3,4,5-trimethoxyphenyl)thien...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195893(3-(2,3-dichlorophenyl)-7-(3,4,5-trimethoxyphenyl)t...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195885(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 389nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195883(7-bromo-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]py...)copy SMILEScopy InChI
Affinity DataIC50: 575nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195885(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 933nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195880(3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195885(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195891(3-(naphthalen-2-yl)-7-(3,4,5-trimethoxyphenyl)thie...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195889(3-(pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)thieno[...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195881(3-(4-methoxyphenyl)-7-(3,4,5-trimethoxyphenyl)thie...)copy SMILEScopy InChI
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3bMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3bMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195886(3-(4-(methylsulfonyl)phenyl)-7-(3,4,5-trimethoxyph...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195894(1-(4-(4-amino-7-(3,4,5-trimethoxyphenyl)thieno[3,2...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195882(2-(3-(4-amino-7-(3,4,5-trimethoxyphenyl)thieno[3,2...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195887(3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed