Compile Data Set for Download or QSAR
Found 57 Enz. Inhib. hit(s) with all data for entry = 50018534
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50609298(CHEMBL5268404)copy SMILES
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609298(CHEMBL5268404)copy SMILES
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50122787(2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...)copy SMILEScopy InChI
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCorticotropin-releasing factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataKi:  1.69E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)copy SMILES
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)copy SMILES
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609288(CHEMBL5268087)copy SMILES
Affinity DataIC50: 0.310nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)copy SMILEScopy InChI
Affinity DataIC50: 0.488nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50609297(CHEMBL5285673)copy SMILES
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetProteinase-activated receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50609292(CHEMBL5273903)copy SMILES
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)copy SMILEScopy InChI
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609297(CHEMBL5285673)copy SMILES
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609287(CHEMBL5284720)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
In DepthDetails
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
In DepthDetails
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)copy SMILEScopy InChI
In DepthDetails
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)copy SMILES
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)copy SMILEScopy InChI
In DepthDetails
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMMore data for this Ligand-Target Pair
In DepthDetails
TargetMicrotubule-associated protein tau(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)copy SMILES
Affinity DataIC50: 9.20nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)TBA
LigandPNGBDBM50609296(CHEMBL5282946)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)copy SMILEScopy InChI
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50609295(CHEMBL5269179)copy SMILES
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)copy SMILES
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA
LigandPNGBDBM50609299(CHEMBL5279523)copy SMILES
Affinity DataIC50: 57nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50609291(CHEMBL5281874)copy SMILES
Affinity DataIC50: 75nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 87nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)copy SMILEScopy InChI
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
In DepthDetails DrugBank
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50609294(CHEMBL5280146)copy SMILES
Affinity DataIC50: 120nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)copy SMILEScopy InChI
Affinity DataIC50: 145nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 168nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))TBA
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)copy SMILEScopy InChI
Affinity DataIC50: 363nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTumor necrosis factor(Homo sapiens (Human))TBA
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)copy SMILEScopy InChI
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In DepthDetails
TargetMicrotubule-associated protein tau(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)copy SMILES
Affinity DataIC50: 660nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
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