Compile Data Set for Download or QSAR
Found 79 Enz. Inhib. hit(s) with all data for entry = 50018729
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50021655(DECERNOTINIB | US10112907, Example 00017 | US10766...)copy SMILEScopy InChI
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50611956(CHEMBL2367481)copy SMILES
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM246868(US10053465, 7 | US10065963, Compound 7 | US1012515...)copy SMILEScopy InChI
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50611957(CHEMBL5282343)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50591313(GANDOTINIB | Gandotinib | LY-2784544 | LY2784544 |...)copy SMILES
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)copy SMILEScopy InChI
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)copy SMILEScopy InChI
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50611957(CHEMBL5282343)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50611955(JAK-I | JAKI | OCLACITINIB | Oclacitinib | PF 0339...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)copy SMILEScopy InChI
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)copy SMILEScopy InChI
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)copy SMILEScopy InChI
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK1(Mus musculus)TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)copy SMILEScopy InChI
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)copy SMILEScopy InChI
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)copy SMILEScopy InChI
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)copy SMILEScopy InChI
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50611955(JAK-I | JAKI | OCLACITINIB | Oclacitinib | PF 0339...)copy SMILES
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)copy SMILEScopy InChI
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In DepthDetails
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)copy SMILEScopy InChI
Affinity DataIC50: 25nMMore data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611956(CHEMBL2367481)copy SMILES
Affinity DataIC50: 25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
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