Compile Data Set for Download or QSAR
Found 53 Enz. Inhib. hit(s) with all data for entry = 50021425
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224400(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224396(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224402(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)copy SMILEScopy InChI
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224409(9-(4-chlorophenyl)-2,3-dihydro-2(R)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224393(8-(4-chlorophenyl)-1h-imidazo[4'',5'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224390(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224403(8-(4-methylphenyl)-1H-pyrazolo[3'',4'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224401(8-(4-chlorophenyl)-1h-pyrazolo[3'',4'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224398(8-(4-methoxyphenyl)-1h-pyrrolo[2'',3'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataKi:  29nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224394(8-(4-chlorophenyl)-1-methyl-1H-imidazo[4'',5'':4',...)copy SMILEScopy InChI
Affinity DataKi:  104nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224389(8-(4-methylphenyl)-2-(methylthio)thiazolo[4'',5'':...)copy SMILEScopy InChI
Affinity DataKi:  788nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224399(8-(4-methylphenyl)thiazolo[4'',5'':4',5']pyrido[3'...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224404(1,2-dihydro-8-(4-methylphenyl)-2-thioxothiazolo[4'...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224402(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224390(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224396(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224398(8-(4-methoxyphenyl)-1h-pyrrolo[2'',3'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224400(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224408(8-bromo-3-(4-chloro-phenyl)-9-methylamino-3H-pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224393(8-(4-chlorophenyl)-1h-imidazo[4'',5'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224394(8-(4-chlorophenyl)-1-methyl-1H-imidazo[4'',5'':4',...)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224403(8-(4-methylphenyl)-1H-pyrazolo[3'',4'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224409(9-(4-chlorophenyl)-2,3-dihydro-2(R)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224401(8-(4-chlorophenyl)-1h-pyrazolo[3'',4'':4',5']pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224399(8-(4-methylphenyl)thiazolo[4'',5'':4',5']pyrido[3'...)copy SMILEScopy InChI
Affinity DataIC50: 446nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224404(1,2-dihydro-8-(4-methylphenyl)-2-thioxothiazolo[4'...)copy SMILEScopy InChI
Affinity DataIC50: 541nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224400(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 609nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224389(8-(4-methylphenyl)-2-(methylthio)thiazolo[4'',5'':...)copy SMILEScopy InChI
Affinity DataIC50: 636nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataIC50: 702nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224396(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224409(9-(4-chlorophenyl)-2,3-dihydro-2(R)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224390(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MQXPubMed
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